WALTHAM, Mass., Oct. 03, 2018 (GLOBE NEWSWIRE) -- Entasis Therapeutics (NASDAQ: ETTX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel antibacterial products, today announced an oral presentation at the Infectious Disease Society of America (IDSA) IDWeek™ 2018 taking place October 3 - 7, 2018 in San Francisco, California. The presentation will provide an overview of ETX2514SUL, Entasis’ β-lactamase inhibitor, ETX2514, in combination with sulbactam. ETX2514SUL recently completed a Phase 2 study for the treatment of complicated urinary tract infections (cUTI) and acute pyelonephritis in adults. ETX2514SUL is being developed for the treatment of a variety of serious multidrug-resistant infections caused by Acinetobacter baumannii.

Details of the presentation are as follows:

Oral Presentation: ETX2514/sulbactam
Presenter: Robin Isaacs, M.D.
Session: Exploring the Antibiotic Pipeline 2018 Symposium
Date and Time:Thursday, October 4, 20183:00 PM
Location: Room N Hall D

A Phase 3 clinical trial evaluating ETX2514SUL against carbapenem-resistant A. baumannii infections will begin in the first quarter of 2019.

About ETX2514
ETX2514 is a potent and broad-spectrum inhibitor of class A, C, and D β-lactamases. ETX2514 restores the in vitro activity of multiple β-lactams against Gram-negative, multidrug-resistant (MDR) pathogens. Entasis Therapeutics is initially developing ETX2514SUL, the combination of ETX2514 and sulbactam, for the treatment of severe A. baumannii infections. Sulbactam is a generic β-lactam which has intrinsic activity against A. baumannii but suffers from widespread β-lactamase-mediated resistance. In preclinical studies, ETX2514 restored sulbactam antibacterial activity against A. baumannii. ETX2514 has completed single- and multi-ascending dose Phase 1 trials and a Phase 2 trial, in combination with sulbactam, in cUTI. The U.S. Food and Drug Administration (FDA) has granted Qualified Infectious Disease Product (QIDP) designation and Fast Track status to ETX2514SUL for the treatment of hospital-acquired and ventilator-acquired bacterial pneumonia and bloodstream infections due to A. baumannii.

About Entasis
Entasis Therapeutics is developing a portfolio of innovative product candidates to treat serious Gram-negative multi-drug resistant bacterial infections.  Entasis’ anti-infective discovery platform has produced a pipeline of meaningfully differentiated programs which target serious bacterial infections, including ETX2514SUL (targeting Acinetobacter baumannii infections), zoliflodacin (targeting Neisseria gonorrhoeae), ETX0282CPDP (targeting Enterobacteriaceae infections), and Non-Beta-lactam PBP inhibitors or NBPs (targeting Gram-negative infections). www.entasistx.com

Forward-Looking Statements
This press release includes certain disclosures which contain “forward-looking statements,” including, without limitation, statements regarding Entasis’ expectations regarding the commencement of trading of its shares on the Nasdaq Global Market, the completion and timing of the closing of the public offering, and the expected amount of gross proceeds from the offering.  Forward-looking statements are based on Entasis’ current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict.  Factors that could cause actual results to differ include, but are not limited to, market conditions, risks and uncertainties related the satisfaction of customary closing conditions related to, and the completion of, the public offering.  Many of these factors are beyond Entasis’ control.  These and other risks and uncertainties are described more fully in the section titled “Risk Factors” in the final prospectus related to the public offering to be filed with the Securities and Exchange Commission.  Forward-looking statements contained in this announcement are made as of this date, and Entasis undertakes no duty to update such information except as required under applicable law.

Company Contact
Kyle Dow 
Entasis Therapeutics   
(781) 810-0114       
kyle.dow@entasistx.com   

Investor Contact
Chris Brinzey
Westwicke Partners
(339) 970-2843
Chris.brinzey@westwicke.com

Media Contact
Kari Watson or Stefanie Tuck
MacDougall Biomedical Communications
(781) 235-3060
kwatson@macbiocom.com or stuck@macbiocom.com

Source: Entasis Therapeutics Holdings Inc.