Entasis Therapeutics Presents Data Highlights from Phase 3 ATTACK Trial at 2022 American Thoracic Society Annual Conference
The poster presentation―P628 Sulbactam-Durlobactam (SUL-DUR) Treatment Is Associated with Lower Mortality from Index Acinetobacter Infections in the Attack Phase 3 Registrational Trial―presented key data from the landmark ATTACK trial. Sulbactam-durlobactam is an investigational drug in development for the treatment of infections caused by Acinetobacter baumannii including carbapenem-resistant and multi-drug resistant strains.
Key findings in this presentation include:
- There was a notable divergence in all-cause mortality between days 6-14 with higher rates of mortality in the colistin treatment arm. All-cause mortality rates were similar in the SUL-DUR and colistin arms during days 0-5 and 15-28 after the start of therapy
- Twice as many deaths occurred in the colistin arm than in the SUL-DUR arm through Day 28
- Investigator-assessed deaths related to the index carbapenem-resistant Acinetobacter baumannii-calcoaceticus infection occurred more frequently during days 6-14 in the colistin arm
- Patients in the colistin arm who died during days 6-14 (60 ± 16 years) were younger than patients who died during days 0-5/15-28 (78 ± 12 years)
- These observations suggest that deaths early in treatment were more attributed to failure of treatment of Acinetobacter while deaths later in treatment were due to underlying co-morbidities
“We are pleased to share data from our Phase 3 ATTACK trial at ATS 2022, the first time we presented these highlights at a medical congress of pulmonary and critical care specialists,” said
The ATTACK trial was conducted to evaluate the efficacy and safety of SUL-DUR versus colistin, both in combination with imipenem/cilastatin, for patients with Acinetobacter baumannii-calcoaceticus (ABC) infections, including carbapenem-resistant and multidrug-resistant strains. The trial consisted of two parts: Part A was a randomized, blinded noninferiority study (SUL-DUR versus colistin; non-inferiority margin 20%) in
In 2021, Entasis announced the initiation of the Expanded Access Program (EAP.) in the US. For information on the program, requests and questions please submit these to Expandedaccess@entasistx.com.
Entasis is a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Entasis’ pathogen-targeted design platform has produced a pipeline of product candidates, including SUL-DUR (targeting Acinetobacter baumannii infections), zoliflodacin (targeting Neisseria gonorrhoeae infections), ETX0282CPDP (targeting Enterobacterales infections) and ETX0462 (targeting Gram-negative infections including Pseudomonas). For more information, visit www.entasistx.com.
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Source: Entasis Therapeutics Holdings Inc.