United States securities and exchange commission logo

                         October 8, 2020

       Elizabeth Keiley
       General Counsel
       Entasis Therapeutics Holdings Inc.
       35 Gatehouse Drive
       Waltham, Massachusetts 02451

                                                        Re: Entasis
Therapeutics Holdings Inc.
Statement on Form S-3
                                                            Filed October 5,
                                                            File No. 333-249315

       Dear Ms. Keiley:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact James
Young at 202-551-4679 with any questions.


                         Division of Corporation Finance

                         Office of Life Sciences
       cc:                                              Jack Bodner