35 Gatehouse Drive
Waltham, Massachusetts


October 9, 2020



U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: James Young


Re:Entasis Therapeutics Holdings Inc.

Registration Statement on Form S-3

Filed October 5, 2020

File No. 333-249315


Ladies and Gentlemen:


Pursuant to Rule 461 under the Securities Act of 1933, as amended, Entasis Therapeutics Holdings Inc. (the “Company”) hereby respectfully requests that the effective date for the registration statement referred to above be accelerated so that it will become effective at 9:00 a.m., Eastern time, on October 13, 2020, or as soon as practicable thereafter.


Should you have any questions regarding the foregoing, please call the Company’s counsel, Brian K. Rosenzweig or Reid S. Hooper of Covington & Burling LLP, who can be reached at (202) 662-6000.


Thank you for your assistance in this matter.


  Very truly yours,
  Entasis Therapeutics Holdings Inc..
  By: /s/ Elizabeth M. Keiley
  Name: Elizabeth M. Keiley
  Title: General Counsel